Classes for Spring 2012
List of all the courses taught:
BIO L 4531 Molecular Biology
BIOL 4522 Molecular Biology Laboratory
BIOL 4523 Lab for Biotech
BIOL 4534/ CSCI 4931 Intro to Bioinformatics
BIOL 4436 Pathophysiology
BIOL 4728 Seminar in Biology
BIOL 4631 Immunology
BIOL 5132 Advances in Molecular Biology
BIOL 5731/ BIOT 5031 Applied Biotechnology
BIOL 5931 Research Topics in Biology: Patho-physiology
BIOT 5131 Advanced Methods in Biotechnology I
BIOT 5132 Advanced Methods in Biotechnology II
BIOL 5738 Gene Therapy
BIOL 5530 Research Methods
BIOL 6838 Research Project & Seminar
of Science and Computer Engineering
Address: 2700 Bay Area Blvd., Houston, TX 77058
Ph.D. (Molecular Genetics) 1994
University Medical School, Japan.
Dhaka Medical College, University of Dhaka,
L. Kirschstein National Research Service Award
Scholarship (Ministry of Education, Science & Culture, Japan), 1989
Bangladesh National Board Scholarship for Medical
Research Service Award Fellow 03/00- 01/03
-Dept. of Medicine, Baylor College of Medicine,
Post-doctoral Research Associate 09/94-
-Cellular Biology, University of Georgia
Medical Officer/ Assistant Surgeon 06/87-06/89
-Ministry of Health, Bangladesh
-Dhaka Medical College Hospital, Dhaka, Bangladesh
- Regulation and localization of proteins/enzymes
aiming towards vaccine development or chemotherapy
- Cloning of novel genes to study roles in
pathophysiology in human diseases
- Universal expression of genes in both
prokaryotes and eukaryotes
- Mechanism of DNA replication
UHCL Faculty Research Support Fund(2003-2010): $
NIH-NICHD AREA Grant: New Human Inducible Nitric
Oxide Synthase-binding Proteins in Testis: Possible Role in Fertility. $341,934
(Funded; funding ends September 2013) -PI
Nitric oxide (NO) is a cell
signaling molecule and involved in numerous biological processes, including
vasodilatation, neurotransmission, macrophage mediated immunity and
carcinogenesis. Nitric oxide (NO) is differentially formed in almost all
types of human cells by two constitutive and one inducible form of nitric
oxide synthases (NOS). NO synthesized by eNOS and nNOS are beneficial for the
physiological processes in cells. Inducible form of NOS, however, synthesizes
NO in excess, which may prove to be harmful to cells. This may also be the
reason for the inflammation based infertility in males as a result of reduced
motility of sperm cells in testis. Hence it has become necessary to
specifically inhibit iNOS to cure inflammation based infertility as well as
number of other conditions involved with increased NO. One way to inhibit
iNOS is by targeting proteins that interact with it. Therefore,
identification of those iNOS-interacting key proteins are essential which
should not affect other NOSs thus maintaining the physiological NO level. We
can achieve this by screening the human testis cDNA library using iNOS as a bait employing a yeast two-hybrid system.
PJ, Rashid MB and Eissa NT, 2003. Intracellular formation of "undisruptable" dimers of inducible nitric oxide
synthase. Proc Natl Acad Sci U S A. Nov 25;100(24):14263-8
MB, Stanton JD and Mensa-Wilmot K, 2002. Cysteine-less GPI-phospholipase
C is Inhibited Competitively by a Sulfhydryl Reagent: Glyco-mimicry by para-Chloromercuriphenylsulfonate
(Biochem J. Aug 15; 366(Pt
- Ghosh DK, Rashid MB, Crane B, Taskar
V, Mast M, Misukonis MA, Weinberg JB, Eissa
NT, 2001. Characterization of key residues in the subdomain encoded by
exons 8 and 9 of human inducible nitric oxide synthase: a critical role
for Asp-280 in substrate binding and subunit interactions. Proc Natl Acad Sci U S A. Aug 28;
- Rashid MB and Mensa-Wilmot K, 2000. A novel
kanamycin/neomycin phsophotransferase cassette
increases transformation efficiency of E. coli. Biotechniques (January)
- Rashid MB, Russell M and Mensa-Wilmot K, 1999.
Roles of Gln81 and Cys80 in Catalysis by GPI-Phospholipase C from Trypanosoma brucei. Eur J Biochem. Sep 15;
- Teilhet M, Rashid MB, Hawk A, Al-Qahtani
A and Mensa-Wilmot K, 1998. Effect of short 5’ UTR on protein synthesis
in two biological kingdoms. Gene 222: 91-97.
- Rashid MB, Shirahige
K, Ogasawara N and Yoshikawa H, 1994. Anatomy of the stimulative
sequences flanking the ARS consensus sequence of chromosome VI in S.
cerevisiae. Gene 150: 213-220.
- Yamazoe M, Shirahige K,
Rashid MB, Kaneko Y. Nakayama T, Ogasawara N, Yoshikawa H, 1994 A
protein which binds preferentially to single-stranded core sequence of
autonomously replicating sequence is essential for respiratory function
in mitochondria of S. cerevisiae. J Biol
Chem. 269: 15244-15252.
- Shirahige K, Iwasaki T, Rashid MB, Ogasawara N and
Yoshikawa H,1993. Location and characterization
of autonomously replicating sequences from chromosome VI of Saccharomyces
cerevisiae. Mol Cell Biol
- American Thoracic Society, San Francisco, CA.
May'01; Characterization of Key residues in the region of exons 8-9 of
human iNOS: Asp280 is critical for substrate binding and subunit
- FASEB Experimental Biology, Orlando, FL.
Mar'01; Characterization of Key residues in the region of exons 8-9 of
- Molecular Parasitology Meeting X, Marine
Biological Laboratory, Woods Hole, MA Sep'99. Contribution of
non-covalent interactions to inhibition of GPI-Phospholipase(s) C by a
sulfhydryl reagent: identification of a putative target for p-CMPS
inhibition of GPI-PLC from T. brucei.
- Molecular Parasitology Meeting IX, Marine
Biological Laboratory, Woods Hole, MA. Sep'98; Possible roles of Gln81
and Cys80 in Catalysis by GPI-Phospholipase C from T. brucei.
- Cellular Biology Departmental Seminar,
University of Georgia, Athens, GA.
Jan'96; Anatomy of the autonomously replicating sequences in S.
- Annual Molecular Biology Meeting, Tokyo, Japan,
Dec'93; Study of the stimulative sequences of
ARSs on chromosome VI of S. cerevisiae.
- Annual Molecular Biology Meeting, Kyoto, Japan,
Dec'92; Title: Fine analysis of the type I ARSs (Autonomously
replicating sequences) on chromosome VI of S. cerevisiae
UNDERGRADUATE RESEARCH OPPORTUNITIES:
UNDERGRADUATE STUDENTS ARE ENCOURAGED TO
JOIN MY RESEARCH TEAM ON AN NIH PROJECT.
CONTACT IMMEDIATELY IF YOU ARE